US Open Quarterfinals 2025 – Discover the Best Bets for and US Open Odds for all the Matchups

Last updated: September 2, 2025

The last Grand Slam tournament of the year is already underway, with the quarterfinal matchups set up last night. Barring a few early surprises, the ATP US Open quarterfinals feature the world’s top players. Top seeds are looking to book a spot in the semifinals, but no player who reached the quarters can be written off.

As soon as the quarterfinals matchups are set, excitement builds up in regards to the US Open odds. There’s growing interest in this state of the tournament, even for bettors who haven’t placed any wagers before. Our US Open quarterfinal betting tips and predictions will break down all the matches, providing bettors with expert tips and best bets at the US Open.

US Open Quarterfinals Betting Predictions

Things haven’t changed much since our last US Open betting predictions. Jannik Sinner is still the main favorite to win the trophy, followed by Carlos Alcaraz. Both of them have booked a spot in the US Open quarterfinals, which might lead to a clash in the final.

Here are the top US Open betting odds for the players still alive in the quarters.

US Open Quarterfinal Draw and Betting Predictions

The best bets US Open are right here on this page. With the quarterfinals underway from September 2, we’ll have our US Open betting predictions below for all four matchups.

Jiri Lehecka vs Carlos Alcaraz

Czech player Jiri Lehecka and Carlos Alcaraz will meet for the 4^th time on Tuesday. The Spaniard leads the head-to-head with 2-1, defeating Lehecka this summer at Queen’s Club 2-1. While Alcaraz is the overwhelming favorite in this matchup and for the title, Lehecka has performed great in the past few months.

Of course, Alcaraz will prove a big challenge for the Czech, so it can be tough for him to defy US Open betting predictions and odds. Experts believe a surprise is not on the cards, aiming for a comfortable win for Carlos Alcaraz.

Why? The stats show it. Alcaraz has won 43 of his last 45 matches, losing only once to Sinner in the Wimbledon 2025 final. He’s been on a tear at the US Open this year, and considering his quality, he leads our best bets BetPlays US Open list for the quarterfinals.

• Best bet: Alcaraz moneyline or Alcaraz to win 3-0

Novak Djokovic vs Taylor Fritz

Even at the age of 36, Djokovic continues to defy any expectations. He’s right behind the Sinner/Alcaraz duo in US Open betting predictions, and still has the quality to win that elusive 25^th Grand Slam title. This year, Djokovic has been in great form at the US Open, reaching the quarterfinals with no scares.

In the US Open quarterfinals, he’ll face American Taylor Fritz. Djokovic has a perfect 10- H2H against Fritz, although the American has the support of the home crowd. Additionally, the aging Djokovic dropped a few sets on his way to the quarterfinals, which might present a US Open betting opportunity for Fritz fans.

Our best US Open quarterfinals betting predictions recommend a Djokovic win or a live bet on Fritz. It’s almost given that Fritz will take a set of Novak, so maybe a late break and a live set pick on Fritz is the best idea for this matchup. Also, bettors should keep in mind that Fritz played the final against Sinner last year. He’s younger than Djokovic, and probably the only underdog in the quarters that can pull off a surprise.

• Best bet: Djokovic to win or Fritz live-set bet

Jannik Sinner vs Lorenzo Musetti

As the world number 1, Jannik Sinner has obliterated opponents at the US Open so far. He’s also the leader per US Open betting predictions, with top odds to reach the final and win the trophy. So far, there was no challenge for Sinner, with Lorenzo Musetti aiming to upset the world’s best tennis player at the moment.

While strong, Musetti’s form at Grand Slams has been inconsistent. Sinner breezed past Alexander Bublik in the previous round. Bublik didn’t lose a serve before meeting the Italian, but was defeated in a clinical match with 6-1, 6-1, 6-1. With the last win, Sinner extended his hard-court dominance. Betting experts believe Jannik Sinner is in for another 3-0 win, which is one of the best bets for the US Open.

• Best bet: Sinner wins 3-0 or Sinner moneyline

Felix Auger-Aliassime vs Alex de Minaur

The most interesting match in the US Open quarterfinals for neutral tennis fans and bettors is the matchup between Felix Auger-Aliassime and Alex de Minaur. Canadian player Auger-Aliassime has been having a few quiet years before bursting to the quarterfinals this year. He upset Andrey Rublev in the previous round, announcing his desire to reach a first US Open semifinal.

Alex de Minaur is a proven hard-court player who’s looking for a first semifinal appearance as well. Per the latest US Open quarterfinal betting predictions, Auger-Aliassime holds a slight edge. Bettors should also consider the match to go the distance, as de Minaur’s prowess on hard courts might prove a challenge for Auger-Aliassime.

• Best bet: Auger-Aliassime win or match to go the distance

US Open Best Bets at a Glance

Here’s a preview of the best bets US Open markets for each match in the quarterfinals. These are just our US Open betting predictions. Bettors are advised to do research on all the players and their H2H stats before making a decision.

What Are the Most Likely US Open Quarterfinals Winners?

Sinner, Auger-Aliassime, Djokovic, and Alcaraz will most likely advance from the US Open quarterfinals. Bettors should take a look at live bets for Fritz and Auger-Aliassime that might bring decent value. A parlay is a good option, especially when choosing moneylines over other tennis betting markets.

FAQ

Who are the Favorites in the US Open Quarterfinals?

The current winners per the latest US Open odds include Djokovic, Sinner, Alcaraz, and Auger-Aliassime. However, BetPlays offers betting in different markets for the US Open, so bettors should explore opportunities before placing a wager.

What are the Best Betting Markets for US Open Matches?

The best betting markets include moneylines, set betting, and live bets. We advise bettors to look for betting value, which can be found in live betting markets as well as prop bets.

Can Underdogs Win in the Quarterfinals?

Of course. Surprises are likely to happen all the time. Tennis players often display their true value in the knockout rounds at Grand Slams, so keep this in mind before you place your wagers.

How do Live Betting Odds Shift During Matches?

Live tennis betting odds shift depending on the conditions and score of an in-play match. For example, the odds for Djokovic will go higher if Fritz leads after one set. The player’s form during the match can also cause a shift in the odds.