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NFL Week 17 Predictions – Find the Best Picks from NFL’s Penultimate Week This Season

Betting NFL late season is a great pick for experienced bettors as most playoff spots are already set. The top NFL Week 17 predictions are here, with the season on the line for many teams. The penultimate week in the regular season is sure to bring drama. There are huge playoff implications for some teams, while others will just be looking to trip over contenders and make their playoff harder.
BetPlays’s NFL Week 17 picks are listed below. We’ll cover the most exciting matches for Week 17 NFL betting, including spreads, totals, and moneyline picks. Read on as we take a dive into the NFL Week 17 best bets, which may seal the destiny for many favorites.
NFL Week 17 Overview
Week 17 has already started, with the Broncos overcoming the Chiefs. Cowboys also beat the Commanders, while the Vikings triumphed over the lions.
Much better matches are set to follow with major playoff implications right after Christmas and before the New Year. It’s a time where injuries, tiredness, and rotations are in the focus, which strongly affects each team’s NFL Week 17 odds.
Take a look at the full schedule before we dive into the top NFL Week 17 predictions and betting tips.
| NFL Week 17 Matches | |
| Commanders | Cowboys |
| Vikings | Lions |
| Chiefs | Broncos |
| Chargers | Texans |
| Packers | Ravens |
| Dolphins | Buccaneers |
| Jets | Patriots |
| Browns | Steelers |
| Colts | Jaguars |
| Bengals | Cardinals |
| Raiders | Giants |
| Bills | Eagles |
| 49ers | Bears |
| Falcons | Rams |
With some teams fighting to stay alive while others are locked into postseason slots, Canadian bettors have excellent betting opportunities with our NFL Week 17 picks.
Top NFL Week 17 Betting Predictions
The best bets including spreads, totals, and moneylines are listed for each of the top NFL Week 17 matches below. We’ve based this on form, match-ups, injuries, and betting value, with the best NFL Week 17 odds listed right here at BetPlays.
We’ll start things off with a derby, then continue with the top NFL picks this week and other important NFL Week 17 predictions. Player props and other suggestions will come a bit later in the article along our NFL Week 17 betting tips.
Packers vs Ravens
The Packers meet the Ravens in what’s likely the most interesting game in NFL Week 17. Packers haven’t booked a spot in the playoffs so far, so they’ll be looking for a win at home. Lamar Jackson is doubtful for the Ravens, and that will be a big problem for Baltimore offensively. Jordan Love is out, too, so this might be a game of unders.
The moneyline is in the Packers’ favor, and we can’t look past Green Bay for the win. Sorry, Ravens fans. The team started the season as a contender, but inconsistent play and injuries have derailed the postseason train. That loss against the Patriots last week hurt a lot. Better luck next year, we guess.
Colts vs Jaguars
The Jacksonville Jaguars have had a stellar season so far with a record of 11-4. AFC South is potentially on the line, so this will be a cautious game against the Colts.
With the playoff race in full swing for the Colts, once among the Super Bowl contenders, it will be a difficult match for Indianapolis to keep postseason hopes alive. It’ll be a mountain of a task, though, so it’s best to explore the unders market in the BetPlays sports betting section.
We’re just glad we’re having a division rivalry such late in the season. Bettors should also explore some player props, as sone of the top BetPlays NFL Week 17 odds lie there for this clash.
Bengals vs Cardinals
The Bengals have been far more impressive with Joe Burrow in the lineup. They should have enough in the tank to beat the sluggish Cardinals. Arizona is also struggling defensively, opening up offensive opportunities for the Bengals.
As an underdog, the Cardinals have better NFL Week 17 odds. But that’s a heavy mountain to climb, especially with them being out of the playoff race. Our recommendation for this match are player props NFL Week 17 picks, especially on Joe Burrow’s side. Canadian bettors looking at moneylines can go with either team, but the Bengals are a clear favorite here. Maybe a look at the NFL totals Week 17 odds provides better value, with over 45.5 being the best bet.
Keep an eye on live betting markets. This could be a close game, and fast thinking works well with in-play markets at BetPlays.
Bills vs Eagles
A high-profile match with two elite offenses, the Bills and Eagles will lock horns on Sunday at 4:25 PM ET. Saquon Barkley takes the top spot in player props Bills vs Eagles predictions, as he’s facing a Buffalo team that ranks 30th in rush defense.
The Eagles have secured the NFC East crown, and are entering the playoffs as Super Bowl contenders. Josh Allen remains one of the best players in the league and an MVP pick. Look at the total points in a match that will come close. Weather conditions may play a big part in your NFL Week 17 predictions, making this game one of the better NFL Week 17 betting picks.
49ers vs Bears
The 49ers and Bears enter this match-up with the same record of 11-4. San Francisco’s offense has been nothing short of stellar, but so is the Bears’ offense. There’s no heavy favorite in this game, so bettors should take a look at other NFL betting options for this game, including rushing yards for the QBs.
During NFL Week 16, the 49ers blew past the Colts, while Chicago beat the Packers. It’s another exciting match to follow in our NFL Week 17 predictions, with overs and unders looking like a real possibility. Most experts go with 49ers NFL moneyline picks this week, but hey, Chicago has beaten expectations this season several times.
Player props might be among the NFL Week 17 best bets for this close game, as moneylines don’t offer that much of a value.
NFL Week 17 Tips, Props, and Best Picks
- For our NFL Week 17 betting tips, we’ll start by watching the weather. Wind, rain, and snow will surely impact the totals. Poor conditions warrant a look at unders for each match, especially the close ones.
- When creating your NFL Week 17 picks, it’s important to prioritize motivation this late into the season. Those running for playoff spots will play with a higher intensity. Because of this, such teams are safer betting options.
- Targeting player props is also a good idea. Injuries, mismatches, and other conditions create value in QB passing yards, rushing totals, as well as anytime TD scorers. Just to be on the safe side, check the lineups before each match, as there might be rotations.
- As always, we also recommend betting responsibly. Keep an eye on your bankroll, don’t go all-in on favorites, and don’t chase your losses.
NFL Week 17 Betting – Final Thoughts
Just like the case so far, NFL Week 17 offers strong betting value. Compared to the previous weeks, it requires a bit more research and a different approach, as playoffs are on the line.
Bettors should focus on team motivation and check the lineups and weather before each match. Be selective with your NFL Week 17 picks, manage your bankroll wisely, and avoid chasing the late-season hype. As always, we suggest reading our NFL Week 17 predictions before visiting the BetPlays sports betting lobby and making your picks.
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