NFL Week 10 Predictions: Betting Picks & Scores

The NFL Week 10 is here, and we’ve got the best NFL Week 10 predictions and picks for this round of American football. This week, the slate includes a match in Berlin, where the Atlanta Falcons will take on the Indianapolis Colts, one of the highest-rated NFL betting picks for the coveted Super Bowl trophy.

Elsewhere, the Ravens take on the Vikings in a match where Lamar Jackson is expected to make a splash. Our Week 10 NFL picks also include a potentially salivating match between the Pats and Buccaneers, where New England can continue its winning streak. Let’s check out the top NFL Week 10 predictions and best bets below.

Top Matchups and Picks for NFL Week 10

Here are the top NFL Week 10 betting picks for the best matches from this week’s action. Take a look at the expert picks below and place your wagers on the top matches at BetPlays.

Baltimore Ravens vs Minnesota Vikings

Our week 10 NFL picks kick off with the match between the Ravens and Vikings. The Baltimore Ravens have Lamar Jackson back, and are further rejuvenated with J.J. McCarthy’s performance against the Lions in Week 9. As the Ravens are getting healthier, they should make a strong push during the second half of the season.

Our Week 10 NFL predictions 2025 suggest a win for the Ravens. Taking the Ravens straight up is a solid choice, and the totals market stands as a pretty solid choice for NFL parlays.

New England Patriots vs Tampa Bay Buccaneers

The Pats are on a strong run, and hiking up the list of NFL Super Bowl favorites. New England has had a strong start to the season under new coach Mike Vrabel and are firing on all cylinders.

While the Buccaneers enter as a favorite, the Patriots’ recent form suggest a solid straight up pick. Canadian bettors should also take a look at other NFL betting markets at BetPlays, including spreads or totals if they aren’t sure for the moneyline favorite. Live NFL betting markets and player props remain a solid choice, especially when it comes to Drake Maye.

Jacksonville Jaguars vs Houston Texans

The Texans will host the Jaguars in one of the closest NFL Week 10 predictions and picks. Experts believe that it’ll be a low-scoring game, as indicated under the totals odds. The Texans have arguably the best defense this year, while the Jaguars offense has been inconsistent. This is one of those matches that can be pretty close. The under 37.5 line looks fine, as the match is too close to call on the moneyline.

Los Angeles Rams vs San Francisco 49ers

The Rams are the superior team compared to the 49ers and have been in better form recently. Matthew Stafford leads the league in passing touchdowns, and is one of the NFL MVP candidates. In the last match between these two teams, the 49ers barely ran off with the win after overtime. However, this time around the Rams should have enough fuel in the tank to outscore the 49ers.

Pittsburgh Steelers vs Los Angeles Chargers

After winning in stunning fashion against the Colts, the Pittsburgh Steelers are on a high. The match against the Chargers comes in just the right time for the Steelers to tie a couple of wins in a row. Both teams have a similar record so far, with the Chargers a game ahead. Our NFL Week 10 betting picks suggest taking the Steelers straight up, as our experts believe they have what it takes to overcome LA.

Philadelphia Eagles vs Green Bay Packers

The Eagles return to action after a bye in Week 9. Here’s a cool fact – Philadelphia is 4-0 when coming off a week of rest. In addition to tradition, Saquon Barkley seems like he’s hitting top speed, and Jalen Hurts is playing at a high level as well. When you take everything into account, the Eagles should win this match, probably tightly.

Let’s not forget that it’s the reigning champion we’re talking about, so despite the NFL Week 10 odds not in their favor, the Eagles are looking good for a win and some profit on your NFL bet slip.

Betting Angles & Best Bets for Week 10

Our NFL Week 10 predictions feature a mix of tight matchups and potential blowouts. As experienced bettors will recognize, this is the perfect condition for finding value bets. Undervalued home teams might provide profit for this round of matches, but so will slight underdogs like the Eagles in the match against the Packers.

Bettors should monitor over/under trends at BetPlays Canada, as the weather starts being a major factor. Outdoor games in colder climates (like Minnesota) often trend toward unders. Indoor matchups are the opposite, delivering strong opportunities for the NFL Week 10 betting picks.

Player props remain among the top Week 10 NLF Picks. They offer plenty of value, especially among players with high red-zone usage or players against weak defenses. Explore all the options at BetPlays and make your picks for the weekend.