NFL Week 16 Predictions – Explore the Top Tips, Odds, and Favorites

With just a few weeks left until the end of the NFL regular season, the tide is rising for many teams. While some are eliminated from playoff contention already, others are very much in the hunt. This makes the NFL Week 16 predictions key for the week before us, where many teams can clinch a playoff berth or drop down from the race.

NFL Week 16 betting markets are already up and running at BetPlays sports. Canadian bettors can find the latest NFL Week 16 odds for the top matches, all of which we’ll preview further below. Our NFL betting analysis will cover the important picks and share a few tips as the race for the playoffs and the Super Bowl heats up.

Full NFL Week 16 Schedule

Week 16 NFL games have already started with the playoff-clinching duel between the Seahawks and the Rams. Seattle won the game last night 38-37 in overtime, so if the game sets the tone for the remainder of Week 16, it’ll be a blast of a round.

Most NFL game times are on Sunday, with a couple of games on Saturday as well. Monday night football Week 16 will feature a game, too, which ends on Tuesday with the Colts and 49ers face-off.

Top NFL Week 16 Betting Picks

Not all NFL Week 16 picks make the cut in our predictions. There are games where favorites will easily beat underdogs that don’t change anything in regards to the playoffs. Then there are match-ups such as the Ravens vs Patriots where there’s a lot on the line.

NFL moneyline picks may not offer the best value for all matches, and underdog picks for the NFL are always risky. The best NFL bets for Week 16 may include overs and unders as well as points spreads and even NFL players props.

The matches we selected offer the best NFL value bets in different markets. Let’s check the previews for the top matches coming later this week.

Packers vs Bears

The largest NFL North rivalry is one of the most anticipated matches in the division every year. It’s the same this year, where both teams are outperforming expectations. The Packers vs Bears odds offer solid value especially in parlays, and it’s almost a safe bet that it’ll be a tight match, which opens up unders opportunities.

It’s just a bad time for the Packers who have lost to Denver in Week 15 and a few key players. Micah Parsons is done for the season with a torn ACL. That win in the derby two weeks ago was great for Green Bay fans, but playing on the road is a different beast. Chicago’s home record is pretty decent, and against the Parsons-led defense, the Bears should win this one.

When it comes to player props NFL betting predictions, Jordan Love is poised for a big game. Keep that in mind when exploring the NFL BetPlays markets.

Bills vs Browns

Our NFL Week 16 predictions continue with an interesting match for the Bills. The Buffalo Bills are coming off a massive road win against the Patriots. Motivation is running high for the team, even if back-to-back road games are tough.

The Browns are out of the playoff race and have offensive issues. With Josh Allen in the fold and aiming for a big game, the Bills should take care of this game. For betting purposes, this match could be interesting for in-play fans, as Buffalo will be looking to take care of things early.

Bengals vs Dolphins

Both teams are eliminated from the playoffs, so the NFL Week 16 odds for this game, especially on the moneyline, won’t be very exciting. With that being said, player props and totals rule the Bengals vs Dolphins predictions. Someone’s poised to break out, and while the game may not be exciting from a fan’s perspective, it certainly is for bettors.

De’Von Achane to have a wild game is among the best NFL Week 16 picks. Check out the BetPlays NFL player props for this match-up and you’ll spot several value bets.

Jaguars vs Broncos

The game of the week. Top-seed Broncos play the Jaguars at home, and both teams have been running strong offense in the last few weeks. It’s a testing game for the Jaguars, who are younger and may be in line for a win on the road.

Both teams are riding impressive win streaks, and one of them will be broken. It’s an evenly-matched game that can go either way. Trevor Lawrence is expected to have a big day, so it’s best to check the NFL Week 16 odds for player props for this match-up. Most experts suggest taking Denver for this one, but the Jaguars won’t come make things easy for the Broncos. If they don’t suffer because of the altitude, it can be a pretty close match.

Patriots vs Ravens

Monday night football betting usually features highlight games such as this one. The New England Patriots have finally lost in Week 15 to the Bills, and are looking to snag another win. However, it will be a stern challenge against the Ravens.

Once again, our NFL Week 16 predictions suggest a tight clash. The Ravens are desperate for a win to stay in the playoff race, while the Pats are looking to avoid losing two in a row. Lamar Jackson will lead the Baltimore Ravens, and considering his caliber, he may even win it. Check out the NFL Week 16 odds in every market, including the Patriots moneyline, as there will be valuable picks in totals, spreads, and even player props.

49ers vs Colts

San Francisco is pushing for a playoff spot, making this game highly important. They won against the Titans last week, but this is another challenge. Additionally, the 49ers defense wasn’t great last week, and the team will be looking to contain Philip Rivers after he almost won the game for the Colts against Seattle last week.

The 49ers are a favorite per NFL Week 16 odds, and they’re among the top picks. Colts’ moneyline offers better value, but it will be a challenge against the 49ers. Brock Purdy is playing well and expected to have another big game. The top NFL Week 16 picks for this game may hide among his props, or checking out the totals or other players at BetPlays Canada.

NFL Week 16 Betting Tips

Late-season motivation plays a crucial part for NFL Week 16 bets. Teams fighting for playoff spots usually deliver more consistent performances. On the other hand, eliminated teams may play at will, which opens up player prop betting opportunities.

Bettors should also take a look for weather reports and latest team news, as December games are usually heavily impacted by the weather. Injuries can also affect totals, offenses, and defenses. For safer bets, we recommend sticking with single bets over large parlays. Compare the odds at BetPlays for all markets before making your NFL Week 16 picks.

As always, we also suggest betting responsibly. Manage your bankroll, keep your bets small, and don’t risk a lot of money on any side. Research is important, but there’s no way to guarantee each outcome, which makes it even more important to bet responsible.

Final Thoughts On Our NFL Week 16 Picks

Our NFL Week 16 predictions offer strong betting opportunities across a range of markets. With just a couple of rounds after this one, we’ll get answers in the playoff races with each week. By analyzing the form, match-ups, and odds movements with BetPlays sports betting, Canadian bettors can find value beyond the moneyline and favorites.

Use our NFL betting predictions to get an idea on how each match might play out. Bet responsible and prioritize value to get the most out of this week’s NFL bets.