NFL Divisional Round Betting Picks & Odds (2026 Playoffs)

Principaux enseignements

• The NFL Divisional Round takes place over the weekend.
• The matchups include Broncos vs Bills, Seahawks vs 49ers, Patriots vs Texans, and Bears vs Rams.
• BetPlays offers the top NFL Divisional Round predictions, tips, and betting odds.
• Learn more about how each matchup may go in our NFL Divisional Round betting picks.

The NFL Divisional Round is here, with the top eight teams, including the top seeds, fighting for the championship game over the weekend. Our NFL Divisional Round betting picks will be posted in the text below along with an overview of the matches.

The second round of the NFL playoffs in 2026 brings a lot of drama and excitement. Our NFL Divisional Round predictions are constructed in a way to help new bettors place their wagers with ease, topped by BetPlays sports betting’s market variety and great NFL Divisional Round odds. Read on to learn some NFL playoff betting tips for the upcoming matches that will give us a clear idea who has a shot at the Super Bowl.

NFL Divisional Round Odds & Matchups Overview

NFL postseason betting is always exciting. Unlike the regular season, there’s no room for errors in the playoffs. That’s what makes the Divisional Round matchups so exciting, and why the playoff weekend betting ahead is a great choice for NFL fans.

The Divisional Round sets the stakes for the championship games and the Super Bowl. From moneyline odds to spreads, totals, and player props, there’s plenty of NFL Divisional Round odds to bet on. With fewer games and higher betting volume as the big game nears, the lines are sharper than the regular season.

Smart Canadian bettors at BetPlays will utilize line movement and early market trends to their advantage. This works perfectly with the best bets NFL Divisional Round we’ll share for each match-up below. Whether you’re a fan of the point spread, moneyline odds, or other NFL playoff lines, you’ll find it all at BetPlays sports betting Canada.

Best NFL Divisional Round Betting Picks

The Conference semifinals are underway this weekend, with the best bets NFL Divisional Round and picks heating up the already buzzing playoff atmosphere. The first seeds jump into action, where winners from the wild card round already await. Sharp bettors are always on the lookout for the top opportunities this late in the season, making their picks after extensive research that provides great betting insights.

Our NFL playoff betting tips, odds, and previews are listed further below. Check out the top favorites for every duel and the best bets for the NFL Divisional Round over the weekend.

Denver Broncos vs Buffalo Bills

The Bills went past the Jaguars in the wild card round, but that left them in a bad state. Despite Josh Allen’s three touchdowns, the team has some injuries that will affect the defense. Despite that, Buffalo ranks high among NFL Divisional Round predictions, entering the game as a slight underdog.

This is the seventh consecutive trip for the Bills to the NFL postseason. They’ve lost to the Chiefs four times, and once to the Bengals and Texans each.

The Broncos lost in the wild-card round to the Bills last year, but this year it’s a completely different scenario. Denver enters the Divisional Round as a favorite, and one of the highest-flying Super Bowl picks.

Considering the Bills’ injury report with several players questionable for the game, our NFL playoff betting tips suggest a Broncos win. Denver should have enough to stop Josh Allen and co. Being a close game, players may look at the over 45.5 market, or get some Josh Allen NFL player props in as the best option.

Seattle Seahawks vs San Francisco 49ers

The classic NFC West tiebreaker has the Seahawks as a major favorite. These teams have met twice earlier this season. San Francisco won in Seattle on the road, while the Seahawks got the revenge game in Bay Area.

Both of the games went over 46 points, so it’s clear that this is one of the best bets NFL Divisional Round. Seattle’s defense showed off over two weeks ago, beating San Francisco and stopping Brock Purdy. This time, the 49ers will need to rely on Christian McCaffred, who will be looking for more than the 23 rushing yards he got in the last match-up against Seattle.

2022 was the last year when Seattle made the playoffs, and it lost the wild card round to the 49ers. A lot of Seahawks’ NFL Divisional Round odds will depend on Sam Darnold. He clarified his status which was questionable yesterday, confirming that he’ll be suiting up.

If the NFL Week 18 round is any indication, the Seahawks should put the 49ers away. Additionally, Brock Purdy’s 1-4 ATS as an underdog in his career doesn’t instill belief that the 49ers would beat Seattle.

New England Patriots vs Houston Texans

Who had the Pats as one of the Super Bowl favorites before the season? Not too many.

Who had the Pats as one of the Super Bowl favorites before the season? Not too many. In the regular season, the Pats went 12-5 against the spread, tied for the best record. The team also had many overs, and covered the last Sunday night against the Chargers.

Drake Maye is one of the NFL MVP favorites, and he’s been in great form all seasons long. However, despite New England’s great record, it has never faced a strong defense like Houston’s.

The Texans have 10 wins in a row, including the wild card win against the Steelers. It cruised to a 30-6 win, and all of Pittsburgh’s six points came in the first half.

It will be a tough match-up for the Pats, but with Drake Maye at the helm, they can hold ground as the heavy favorite. The Pats are on a roll all season, and will be looking for another conference championship game, and, if things go their way, another Super Bowl.

Chicago Bears vs La Rams

Despite being the second seed, the Bears have an unusual situation to face. They’re the home underdogs for the second round in a row. Not that it’ll matter to the team. Chicago looked done and dusted after an early Green Bay lead at the half (21-3). When the Bears started pulling their own weight, it was a done game for Green Bay

This time, the Rams come into the contest after a win against the Panthers. Matthew Stafford, the overwhelming MVP favorite for the regular season, had three passing touchdowns in that game. LA has made three postseason appearances in a row, and won the Super Bowl back in 2021.

The Bears have only one playoff win since 2010, and that was the wild-card round win against the Packers. From a betting perspective, the Bears are one of the most profitable NFL Divisional Round betting picks. But the Rams won’t back down in the Conference semifinals, and have a strong squad that will put Chicago to the test.

Sharp bettors will either go with the Bears or look for overs in this game. Player props, especially Stafford’s touchdowns, are a good idea if you believe the Bears are a risky underdog. Live betting can provide strong opportunities, especially during crunchtime and when one of the team falls behind.

NFL Divisional Round Betting Trends & Stats

When betting on the NFL Divisional Round, Canadian bettors should take a look at key and emerging trends and stats. Home-field advantage means a lot, which is why many experts have the Bears among the best bets NFL Divisional Round.

Bettors should keep an eye on historical trends, last playoff appearances, and regular season matchups between some of the teams. Historical Divisional Round trends can also say a lot. Home teams in playoffs tend to do better, as it’s different playing in front of a home vs away crowd.

Unders often perform well, and are widely recommended NFL playoff betting tips. Such trends can provide valuable context when betting on the NFL Divisional Round. Of course, trends and stats don’t always show the whole picture. Matchup analysis and NFL Divisional Round predictions matter a lot as well, but trends and stats in the playoffs can provide insight into possible wagers, and help bettors avoid common mistakes during one of the most important NFL weekends.

Conclusion: NFL Divisional Round Betting Picks & Final Thoughts

The NFL betting calendar is at its most exciting state, with Divisional Rounds coming this weekend. We’re in the endgame now, and that means no mistakes from any of the teams. The matchups are intense, and traditionally, NFL playoffs are a place of drama, heartbreak, and celebrations.

Elite teams are in the Super Bowl running, with experienced quarterbacks and rising stars taking the stage. High-pressure situations are abound, so success often comes down to preparation, patience, and finding specific betting value.

By reading our NFL Divisional Round predictions and doing match analysis, bettors can spot value accurately at BetPlays. It’s important to approach the playoffs with a clean plan and betting strategy rather than relying on hype or where public money goes. Whether you’re targeting spreads, overs, unders, moneylines, or player props, you’ll find the sharpest NFL playoffs betting odds at BetPlays.

FAQ

When do the NFL Divisional Round Matches Take Place?

The NFL Divisional Round matches are scheduled over the weekend, with one match taking place on Monday. Bettors can place their bets early after reading our NFL Divisional Round picks.

Do Home Teams Have an Advantage in the NFL Divisional Round?

Yes, naturally, home teams do have an advantage in the Divisional Round. Familiar conditions and crowd support matter a lot. Historically, home teams have performed well during this round, although the line values and ATS may differ.

Which Stats Matter Most for NFL Divisional Round Betting?

When betting on the NFL Divisional Round, players should take a look at key NFL Playoffs stats and trends. These include red-zone efficiency, turnover margin, conversion rates, and time of possession. The experience of QBs and defensive matchups also play a role.

Are Unders Profitable in the NFL Divisional Round?

Unders are a historically competitive market in NFL Divisional Round betting. This is mostly due to elite defenses, slower game pace, and conservative plays.