How to Bet on the Bills in 2025 – Buffalo Bills Prop Bets, Totals, Moneylines, Super Bowl Odds, and More

The Buffalo Bills enter the new NFL season as the top favorite for the Super Bowl. The Buffalo Bills odds to win the Super Bowl look great to the team’s fans, and honestly, it’s been a long time coming. Buffalo has won the AFC East 5 times in a row, but has yet to reach the final. This might be the Bills’ year, with some of the best Buffalo Bills bets highlighting the Super Bowl.

BetPlays has a range of NLF betting markets to wager on, including the top Buffalo Bills prop bets and more. Let’s take a look how to be the Bills in 2025 and see what the best Bills markets are.

Buffalo Bills 2024 Season Review

Last year was another heartbreak for Bills fans. After finishing the regular season 13-4 and winning AFC East, they were among the best picks for the Super Bowl. Buffalo Bills prop bets also reigned betting sites, including Josh Allen as MVP which eventually happened. The disappointment came in the AFC Championship game, where the Bills lost 32-29 to the Chiefs.

• Since then, the Bills are tied for most wins in a regular season including playoffs with 15.
• They’re the only team with 61 wins during a 5-season period without a Super Bowl trip.
• Most Buffalo Bills bets this season look similar to last year.
• The Bills are looking to win AFC East once again, but hoping to finally take a trip to the Super Bowl.

What Lies for the Bills Ahead?

The best bets Buffalo Bills you can take in 2025 is the Super Bowl. Experts believe that the team will finally break the curse, and the Bills are in a good position to do so. The Buffalo Bills Super Bowl odds as of right now are +420, well ahead of the Detroit Lions, the Eagles, and Packers.

Of course, nothing happens overnight, and the Bills will have to work hard to look that far ahead. In the offseason, the team didn’t make drastic changes. Larry Ogunjobi and a few draft picks retool the defense, while Joey Bosa replaces Von Miller. Josh Palmer and Elijah Moore have replaced receivers Mack Hollins and Amari Cooper. Josh Allen is once again among the top Buffalo Bills prop bets to repeat as MVP. Head coach Sean McDermott returns, and the Buffalo Bills are nicely tooled for another double-digit winning season.

Will they finally go over the AFC Championship hurdle? Many experts believe so. Josh Allen has established himself as a real star, and with another year of experience, he can lead the team to glory. That’s why one of the best bets Buffalo Bills remains the Super Bowl winner market, with solid odds early in the season.

Best Bets Buffalo Bills

With the NFL betting season in full swing, we’ll take a look at some of the top Buffalo Bills bets for the remaining matches.

Next Buffalo Bills Game Odds

The Bills’ next game is against the Falcons in a match where they’re heavy favorites. The match will be played on October 14, with a range of Buffalo Bills bets available at BetPlays.

Since the Bills are a favorite, the odds for a win are low unless you pick the Falcons. Other popular Buffalo Bills bets for this match include various prop bets, including first touchdown, passing yards totals, rushing yards, and more. There’s a good possibility to build Buffalo Bills parlays with a decent turnaround for sharp bettors.

Source: BetPlays. Odds are subject to change.

Buffalo Bills Prop Bets

Some of the best bets Buffalo Bills have to offer this year include Josh Allen props. As the reigning MVP, Allen is looking forward to another season where he can showcase his talent.

The top Buffalo Bills prop bets right now include Allen to win the MVP (+120 at BetPlays), offensive POY, most pass yards, or passing/rushing totals. Bettors should take a look at all Buffalo Bills bets in this category, as Allen is among the best players in the NFL and looking to crack the records he set last year.

Buffalo Bills Super Bowl Odds

The Buffalo Bills are the main favorite to win the Super Bowl this year. They were among the top favorites last year, but this year’s Buffalo Bills Super Bowl odds are ahead of the competition.

Bettors should take into account the Bills’ inability to reach the final game in the previous seasons. Fans are hopeful that the team has what it takes to do it this year, so there’s a good chance that the Bills enter the Super Bowl as favorites.

Buffalo Bills to Win AFC East

The Bills are currently priced -500 to win the AFC East. Which is no surprise, as the team has won the division five times in a row. This is one of the best bets Buffalo Bills you can take, but due to the price, it may work better on an NFL parlay.

Why Choose Buffalo Bills Bets?

As one of the top and most constant players in the NFL, Josh Allen seems ready to take the next step. This season, the Bills are expected to get better production from their players under the leadership of Allen. Picking him as the MVP or in over/under rushing/passing yards categories remain the best Buffalo Bills prop bets for this season.

Coleman and Kincaid are expected to break out, and the defense has great potential for scoring, too. As long as the team is healthy, Allen included, the Bills once again have a clear path to the AFC East and possibly the Super Bowl.

Reasons to Fade the Bills

The biggest concern for the Buffalo Bills’ season is Josh Allen’s health. Everything’s been solid so far, but given his passionate play, it remains a concern. Also, the Bills might struggle in the receiver position unless Coleman has the season experts believe.

The schedule may also be a bit problematic for the team. From late October, the team has a six-game stretch that starts against the Chiefs. With three road games against playoff-bound teams, the Bills would have to ace this stretch to retain their winning odds.

How to Place Buffalo Bills Bets in 2025?

The best Buffalo Bills bets remain picking the team to win the division and head to the Super Bowl. Josh Allen’s MVP odds look solid as well. Sharp bettors may also want to take a look at Allen to finish under his passing totals, which largely depends on his health.

Nevertheless, there are plenty of good Buffalo Bills prop bets for both team and player to take advantage of. As the season progresses, look for valuable odds at BetPlays and read our tips to bet on the Bills.