Arizona Cardinals Betting Guide 2025 – Explore the Best Arizona Cardinals Betting Line and Props

The Arizona Cardinals endured a difficult time last year. As the season ended, the team focused its efforts in improving the defensive side to erase the negative impact of each Arizona Cardinals betting line and the big point totals on the scoreboard. The offseason brought in new faces in Dalvin Tomlinson and Josh Sweat, along with one familiar face in Calais Campbell.

During the draft, the Cardinals spent the first five picks on defense. With a line that features 2024 breakout star Garret Williams, Zaven Collins, and Budda Baker, the team is stocked on talent on the defensive end. So far, the Cardinals are 2-2 to begin the new NFL season, which mostly mirrors the previous one. In this guide, we’ll show you how place an Arizona Cardinals bet in various markets and present the team’s chances going forward.

Arizona Cardinals NFC West Odds

The Arizona Cardinals currently have the longest odds to win the NFC West Division. There’s still time for the odds to change, but odds-wise, the team is almost the same position as it was last year.

• Arizona Cardinals NFC West Division Winner Odds: +1200

Source: BetPlays. Odds are subject to change.

Arizona Cardinals Super Bowl Odds

At the moment, the Arizona Cardinals betting line for the Super Bowl put the team in the middle of the list of favorites. The Cardinals are a long shot to win the Super Bowl, with the odds heavily impact by how the season progresses and if the Cardinals can tie a string of wins to reach the playoffs in a good spot.

• Arizona Cardinals Super Bowl Winner odds: +8900

Source: BetPlays. Odds are subject to change.

Arizona Cardinals Betting Line for Next Game

The Cardinals play the next game in the NFL against the Titans on October 5. They’re entering the match as the heavy favorite, with the Tennessee Titans still winless this season. The Arizona Cardinals betting line is at -475, which doesn’t bring much excitement for bettors. This is why many will explore other markets such as over under, which should provide more value than the current moneyline odds.

• Tennessee Titans vs Arizona Cardinals: Arizona favorite @ -475

Source: BetPlays. Odds are subject to change.

Arizona Cardinals Prop Bets

When it comes to Arizona Cardinals prop bets, there’s plenty to bet on. Kyler Murray leads the list of prop bets, with total passing touchdowns on offer at BetPlays. Players should also check out Kyler Murray’s MVP odds for the regular season, where he’s not among the top favorites. His dark horse odds may provide value in various statistical categories.

Arizona Cardinals Schedule 2025-2026

How to Bet on the Arizona Cardinals

Placing an Arizona Cardinals bet is easy. BetPlays’ intuitive interface and focus on NFL betting makes things simple for new Canadian bettors. From a single Arizona Cardinals betting line to prop bets and futures, here are the top Cardinals markets to bet on.

Arizona Cardinals Bet Line

The moneyline is the simplest of NFL bets. It’s a bet where wagers are placed on the potential winner of a match. To put things into context, we’ll take the next game against the Titans.

• Cardinals: -475
• Titans: +340

In this case, an Arizona Cardinals bet will win if the team proves its favorite status. As the favorite, the betting line requires $475 to win $100. The Titans are the underdog in this case, paying $440 on a $100 bet ($380 in profit). Moneyline betting focuses simply on the winner, without taking the total points in question.

Point Spreads

Point spreads in the NFL are determined by the points a team wins or loses by. For example, if the Cardinals are favored by over 3.5 points, they must cover the spread by winning 4 points or more. The opponent can lose by 4 points and the bet would still be a winning one.

Point Total O/U

A point total Arizona Cardinals bet refers to the total point scored in a match between the Cardinals and another team. Sportsbooks set a line, for example, 56.5 points, and bettors can predict if the total number of points scored goes over or under it.

If the points scored by both teams go over the line and a wager is placed on that outcome, it’s a winning bet. It’s the same with under. Bettors can correctly predict the lines by studying the offense and defense of the Cardinals as well as the point total in previous games. Last season, the Cardinals had an average O/U totals, varying between 48 and 53 points.

Things are looking similar this year, which is something to keep in mind as the season moves forward.

Futures

Futures are long-term bets that range from the offseason to the full season, with or without the playoffs included. A futures Arizona Cardinals betting line would be to pick the team to win its division or the Super Bowl. Future bets also include award winners such as the MVP, team win totals, and various player performance stats.

Parlays and Teasers

The largest payouts in NFL betting are often secured through parlays. Bettors can wager on several matches on a busy Sunday, predicting various winners via moneylines or teams covering the spread. Teasers are similar to parlays. The big difference is that they allow bettors to move point spreads for more favorable lines at the cost of lower odds.

Live Arizona Cardinals Betting

Live NFL betting is often the best way to bet on the exciting matches. With in-play betting, bettors get unique opportunities to bet on the game while it’s still live. Live bets make for a more immersive experience, where bettors predict the next touchdown.

It’s also a good way to hedge bets at BetPlays. For example, if a bettor picks the Titans in the upcoming game against the Cardinals, and Arizona jumps to an early lead, they could bet on Arizona live to make up for the inevitable loss.