Champions League Playoff Odds & Betting Predictions: Second Leg Deciders

Key Points

• The second leg of the Champions League playoffs kick off on Tuesday and Wednesday.
• Soccer heavyweights such as Inter and Juventus will be desperate for big wins after shocking aggregate deficits.
• Bettors will find value in BTTS and totals markets, especially in matches where trailing teams must push forward.
• Check the latest starting lineups and team news an hour before kickoff for accurate adjustments.

With the second leg deciders in Champions League Tuesday and Wednesday, we’re entering the best part of the competition – the knockout rounds. Teams will line up over the next two days to determine the passengers for the knockouts, which will surely produce some interesting moments. European soccer giants are in action on Tuesday and Wednesday, and the top Champions League playoff odds are live at BetPlays.

The second legs of the playoffs will see favorites trying to erase their mistakes and underdogs to try and hold on for the next round. There were some surprises in the first leg playoffs, including Juventus’ thrashing in Istanbul, and Inter’s shock loss to Bodø/Glimt. We’ll share our Champions League betting predictions for the second leg fixtures and best bets for the upcoming round below.

Tuesday Champions League Tips & Previews

Our Tuesday Champions League tips include the teams that played last week on Wednesday. There’s a massive mountain to climb for former European champions. A thrilling encounter shrouded in controversy is on the books in Madrid, where Benfica will try to erase the one-goal advantage Real Madrid has.

Atlético Madrid vs. Club Brugge

Match	Location and kickoff	Past result (1st leg)	Moneyline favorite
Atletico Madrid vs Club Brugge	Riyadh Air Metropolitano, Madrid, 18:45	Draw 3-3	Atletico Madrid -286

Odds may change.

Who had Club Brugge as Atletico’s bane in Europe on their bingo card? The Madrid side hasn’t won any of its last four games against Brugge, with one loss and three draws. The first leg ended in an exciting 3-3 draw, making the second-leg Champions League betting predictions tricky.

Atletico usually plays well at home. It beat Barcelona 4-0 at the Riyadh Air Metropolitano just weeks ago. But Europe soccer betting is a different beast, and that’s the case with our Tuesday Champions League tips for this match.

Diego Simeone’s team will be kicking itself for letting the lead slip twice in the first leg. This time, it’ll be looking to keep things neat, coming off a win in La Liga over the weekend. The Champions League knockout odds are understandably in Atletico’s favor. Canadian bettors will find value in first goalscorer for Ademola Lookman and Antoine Griezman, as well as Atletico to win both halves.

Club Brugge may mount a challenge, but Atletico has more experience in the CL.

• Best bet: Atletico to win both halves

Inter Milan vs. FK Bodø/Glimt

Match	Location and kickoff	Past result (1st leg)	Moneyline favorite
Inter Milan vs. FK Bodø/Glimt	San Siro, Milan, 21:00	Bodø/Glimt vs Inter: 3:1	Inter -417

Odds may change.

Bodø/Glimt was responsible for the biggest shock of the CL playoff first leg. It won 3-1 at home, putting Inter on the brink of elimination.

With Inter playing at home, the team will come out swinging and look for an early goal. The Champions League knockout odds for Inter to progress are still high, as the Italians have the home crowd as their main weapon. However, second leg fixtures can be tricky if Inter fails to find the net early. With no away goals rule anymore, the team will need to find rhythm in the opening stage and maintain the dominance.

Bodø/Glimt will most likely play defensively, protecting its Champions League playoff odds to progress. Overall, it will be highly interesting to see how this match plays out, as last year’s finalist won’t be looking to lose ground so early.

• Best bet: Inter to win, Inter to score first

Bayer Leverkusen vs. Olympiacos

Match	Location and kickoff	Past result (1st leg)	Moneyline favorite
Bayer Leverkusen vs. Olympiacos	BayArena, Leverkusen, 21:00	Leverkusen win 2-0	Bayer -130

Odds may change.

Bayer Leverkusen has all but finished its job in the first leg of the CL knockouts. A Patrick Schick brace put the hosts in a comfortable position to see off Olympiacos at home. The latest fixed odds before the match prove Bayer’s favorite status.

There’s no reason to believe that Olympiacos can mount a real challenge in Leverkusen. The Champions League knockout odds to progress and win the match for Bayer are understandably high ahead of Tuesday’s match.

Olympiacos will be forced to push upward and score a goal. Bayer Leverkusen could capitalize on these opportunities, making the over 2.5 goals a solid betting angle. For parlay picks, bettors could combine this with Bayer to score over 2 goals.

• Best bet: Over 2.5 goals, Bayer over 2

Newcastle United vs. Qarabağ FK

Match	Location and kickoff	Past result (1st leg)	Moneyline favorite
Newcastle vs. Qarabağ FK	St. James’ Park, Newcastle, 21:00	Newcastle win 6-1	Newcastle -769

Odds may change.

Qarabag is already out of the Champions League unless a miracle happens. The Azerbaijani team trails Newcastle 6-1 with a second leg in England on Tuesday. All Tuesday Champions League tips suggest another goal fest, with Newcastle eager to prove its worth in Europe.

Despite the struggles in the Premier League, Newcastle has shown domination in the favorable tie. It was over for Qarabag before the playoffs even started, and Tuesday could see Newcastle score over 3 goals again.

• Best bet: Newcastle over 3

Wednesday Champions League Tips & Previews

The Wednesday Champions League tips include four more matches to complete the playoffs. Atalanta and Dortmund kick things off at 18:45, followed by PSG vs Monaco, Juventus vs Galatasaray, and Real Madrid vs Benfica.

There will be some desperate teams such as Juventus and Atalanta to defend Italy’s honor, especially if Inter fails the day before. Betting focus is on the most exciting match – Real vs Benfica, where Los Blancos have a narrow lead.

Atalanta vs. Borussia Dortmund

Match	Location and kickoff	Past result (1st leg)	Moneyline favorite
Atalanta vs. Borussia Dortmund	Gewiss Stadium, Bergamo, 18:45	Dortmund win 2-0	Atalanta +113

Odds may change.

Borussia Dortmund did the heavy work in the first leg, winning 2-0 against Atalanta. The German side visits Bergamo firmly in the driving seat, although Atalanta has faced worst situations before.

On the other hand, Dortmund is without a loss against Atalanta in Europe, so it has history on its side. It’s also qualitatively a better squad, with Atalanta losing Ademola Lookman in January to Atletico Madrid.

Everything points to goals on both sides, and most likely a Dortmund win. The Champions League playoff odds for Borussia to win and progress are solid, so most bettors will understandably pick the German side. Dortmund is always lively in attack and isn’t shy to go on the offensive away from home.

• Best bet: Goals on both sides, Dortmund win.

Paris Saint-Germain vs. AS Monaco Champions League Playoff Odds

Match	Location and kickoff	Past result (1st leg)	Moneyline favorite
PSG vs. AS Monaco	Parc des Princes, Paris, 21:00	PSG win 3-2	PSG -357

Odds may change.

The French derby is one of the matches that generate a lot of excitement among bettors. The first match ended in a comeback 2-3 win for PSG, after Luis Enrique’s men went two goals down early.

This time, the reigning CL champions are playing at home, where they’re traditionally at their strongest. Monaco won’t be backing down, and has shown it can challenge Paris Saint-Germain before. Goals on both sides are almost a lock. Bettors can take a look at live betting opportunities after the first goal. Depending on the team that scores it, the others will raise the tempo immediately.

Monaco will be looking to avoid early goals, as it’s already one behind. PSG is an absolute favorite per moneyline odds, with Monaco offering better returns. But this is a match where BTTS and totals are more suitable, as are anytime or first goalscorers.

• Best bet: Both teams to score

Juventus vs. Galatasaray

Match	Location and kickoff	Past result (1st leg)	Moneyline favorite
Juventus vs. Galatasaray	Allianz Stadium, Turin, 21:00	Galatasaray win 5-2	Juventus -189

Odds may change.

Another Italian team appears to be on its way out after Inter. Juventus is in an even worse position than Inter, having lost the first leg 5-2 to Galatasaray.

A lot of things started well for the Turin giants, going 1-0 down and responding with two goals before halftime. Backed up by the fiery atmosphere and its fans, Galatasaray produced a magical second half, scoring four past Juventus to ice the tie.

Juventus is the heavy favorite to win at home, but there are doubts if it can win by at least four to progress. Galatasaray won’t sit down and defend. The Turkish side has a strong attack, and Victor Osimhen is likely to score after missing on goals during the first leg.

The Champions League playoff odds for Galata to progress are low. Moneyline odds offer much better opportunity for profit. With the Old Lady chasing a lot of goals, it’ll be an open game, which warrants a look at the totals market. If the first match is any indication, we’re looking at over four goals easily.

Galatasaray’s blistering attack makes it a perfect target for the Galata to score on the counter market. That, along with in-play opportunities, make this match a perfect fit for Canadian bettors after reading our Wednesday Champions League tips.

• Best bet: Over 4 goals

Real Madrid vs. Benfica Champions League Betting Predictions

Match	Location and kickoff	Past result (1st leg)	Moneyline favorite
Real Madrid vs. Benfica	Santiago Bernabéu, Madrid, 21:00	Real win 1-0	Real Madrid -217

Odds may change.

The final match on Wednesday sees Real Madrid play Benfica at home. Considering the controversy during the first match and Real’s narrow lead, it will be a match to watch closely.

Since the match is played in Madrid, Real will have a huge advantage. Benfica has caused a lot of trouble for Los Blancos before, and will push hard for a goal. But overall, Los Blancos are masters of game management in these stages, so the match might end up with only a few goals.

We can’t see past Real’s quality for this one, even if the moneyline odds don’t offer loads of value. As an underdog, Benfica’s odds look great, but it’ll be a tough climb. Backing up Vini Jr. to score again is a solid pick. Bettors should also take a look at live betting markets, especially surrounding cards, as it’s expected to be an intense match.

• Best bet: Real to win, Under 2.5 goals

Final Thoughts on the UCL Knockout Stage and Champions League Playoff Odds

All Champions League playoff second legs have a do-or-die approach. Tension in the CL is in the air, and our Champions League betting prediction are a solid base for the midweek slate.

With soccer action non-stop in domestic leagues, teams will have to fight tooth and nail to get the result they want. Bettors should keep an eye on the latest lineup news, as sudden injury absences or rotations can drastically change the landscape.

One you’ve reviewed the Champions League playoff odds and tips, you can head to the BetPlays sports betting section and make your picks. With top odds, a selection of pre-match and live betting markets, and bonuses in tow, the upcoming CL slate can be memorable.